United States

Top 538 largest US Companies in the Biotechnology industry by Market Cap

This is the list of the largest public listed companies in the Biotechnology industry from the United States by market capitalization with links to their reference stock.

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Top Biotechnology Companies from the United States as of Jan. 01, 2026

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Rank Company Market Cap (USD) Country Sector Industry
1 Vertex Pharmaceuticals Incorporated $115.92 B United States US Healthcare US Biotechnology
2 Regeneron Pharmaceuticals, Inc. $82.28 B United States US Healthcare US Biotechnology
3 Alnylam Pharmaceuticals, Inc. $52.87 B United States US Healthcare US Biotechnology
4 Seagen Inc. $43.15 B

(Dec. 1, 2023)

 United States US Healthcare US Biotechnology
5 Insmed Incorporated $37.77 B United States US Healthcare US Biotechnology
6 Viela Bio, Inc. $25.88 B United States US Healthcare US Biotechnology
7 Royalty Pharma plc $22.66 B United States US Healthcare US Biotechnology
8 United Therapeutics Corporation $22.46 B United States US Healthcare US Biotechnology
9 Incyte Corporation $19.91 B United States US Healthcare US Biotechnology
10 Revolution Medicines, Inc. $15.28 B United States US Healthcare US Biotechnology
11 BridgeBio Pharma, Inc. $15.08 B United States US Healthcare US Biotechnology
12 Neurocrine Biosciences, Inc. $14.02 B United States US Healthcare US Biotechnology
13 Intra-Cellular Therapies, Inc. $13.50 B

(Jan. 1, 2025)

 United States US Healthcare US Biotechnology
14 Madrigal Pharmaceuticals, Inc. $13.49 B United States US Healthcare US Biotechnology
15 Summit Therapeutics Inc. $13.04 B United States US Healthcare US Biotechnology
16 Ionis Pharmaceuticals, Inc. $12.90 B United States US Healthcare US Biotechnology
17 Moderna, Inc. $12.06 B United States US Healthcare US Biotechnology
18 Karuna Therapeutics, Inc. $11.94 B

(Jan. 1, 2024)

 United States US Healthcare US Biotechnology
19 Exelixis, Inc. $11.73 B United States US Healthcare US Biotechnology
20 BioMarin Pharmaceutical Inc. $11.42 B United States US Healthcare US Biotechnology
21 Avidity Biosciences, Inc. $10.86 B United States US Healthcare US Biotechnology
22 Acceleron Pharma Inc. $10.56 B

(Nov. 1, 2021)

 United States US Healthcare US Biotechnology
23 Arrowhead Pharmaceuticals, Inc. $9.37 B United States US Healthcare US Biotechnology
24 Bio-Techne Corporation $9.29 B United States US Healthcare US Biotechnology
25 Axsome Therapeutics, Inc. $9.01 B United States US Healthcare US Biotechnology
26 OncBioMune Pharmaceuticals, Inc. $8.67 B

(Feb. 1, 2022)

 United States US Healthcare US Biotechnology
27 Blueprint Medicines Corporation $8.30 B

(July 1, 2025)

 United States US Healthcare US Biotechnology
28 Halozyme Therapeutics, Inc. $8.27 B United States US Healthcare US Biotechnology
29 ImmunoGen, Inc. $8.25 B

(Jan. 1, 2024)

 United States US Healthcare US Biotechnology
30 Cytokinetics, Incorporated $7.55 B United States US Healthcare US Biotechnology

Top Biotechnology Companies from the United States as of Jan. 01, 2026

1. Vertex Pharmaceuticals Incorporated

Company Profile: Vertex Pharmaceuticals Incorporated
Market Cap (USD): $115.92 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

2. Regeneron Pharmaceuticals, Inc.

Company Profile: Regeneron Pharmaceuticals, Inc.
Market Cap (USD): $82.28 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

3. Alnylam Pharmaceuticals, Inc.

Company Profile: Alnylam Pharmaceuticals, Inc.
Market Cap (USD): $52.87 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

4. Seagen Inc.

Company Profile: Seagen Inc.
Market Cap (USD): $43.15 B (Dec. 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

5. Insmed Incorporated

Company Profile: Insmed Incorporated
Market Cap (USD): $37.77 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

6. Viela Bio, Inc.

Company Profile: Viela Bio, Inc.
Market Cap (USD): $25.88 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

7. Royalty Pharma plc

Company Profile: Royalty Pharma plc
Market Cap (USD): $22.66 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

8. United Therapeutics Corporation

Company Profile: United Therapeutics Corporation
Market Cap (USD): $22.46 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

9. Incyte Corporation

Company Profile: Incyte Corporation
Market Cap (USD): $19.91 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

10. Revolution Medicines, Inc.

Company Profile: Revolution Medicines, Inc.
Market Cap (USD): $15.28 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

11. BridgeBio Pharma, Inc.

Company Profile: BridgeBio Pharma, Inc.
Market Cap (USD): $15.08 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

12. Neurocrine Biosciences, Inc.

Company Profile: Neurocrine Biosciences, Inc.
Market Cap (USD): $14.02 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

13. Intra-Cellular Therapies, Inc.

Company Profile: Intra-Cellular Therapies, Inc.
Market Cap (USD): $13.50 B (Jan. 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

14. Madrigal Pharmaceuticals, Inc.

Company Profile: Madrigal Pharmaceuticals, Inc.
Market Cap (USD): $13.49 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

15. Summit Therapeutics Inc.

Company Profile: Summit Therapeutics Inc.
Market Cap (USD): $13.04 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

16. Ionis Pharmaceuticals, Inc.

Company Profile: Ionis Pharmaceuticals, Inc.
Market Cap (USD): $12.90 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

17. Moderna, Inc.

Company Profile: Moderna, Inc.
Market Cap (USD): $12.06 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

18. Karuna Therapeutics, Inc.

Company Profile: Karuna Therapeutics, Inc.
Market Cap (USD): $11.94 B (Jan. 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

19. Exelixis, Inc.

Company Profile: Exelixis, Inc.
Market Cap (USD): $11.73 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

20. BioMarin Pharmaceutical Inc.

Company Profile: BioMarin Pharmaceutical Inc.
Market Cap (USD): $11.42 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

21. Avidity Biosciences, Inc.

Company Profile: Avidity Biosciences, Inc.
Market Cap (USD): $10.86 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

22. Acceleron Pharma Inc.

Company Profile: Acceleron Pharma Inc.
Market Cap (USD): $10.56 B (Nov. 1, 2021)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

23. Arrowhead Pharmaceuticals, Inc.

Company Profile: Arrowhead Pharmaceuticals, Inc.
Market Cap (USD): $9.37 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

24. Bio-Techne Corporation

Company Profile: Bio-Techne Corporation
Market Cap (USD): $9.29 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

25. Axsome Therapeutics, Inc.

Company Profile: Axsome Therapeutics, Inc.
Market Cap (USD): $9.01 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

26. OncBioMune Pharmaceuticals, Inc.

Company Profile: OncBioMune Pharmaceuticals, Inc.
Market Cap (USD): $8.67 B (Feb. 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

27. Blueprint Medicines Corporation

Company Profile: Blueprint Medicines Corporation
Market Cap (USD): $8.30 B (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

28. Halozyme Therapeutics, Inc.

Company Profile: Halozyme Therapeutics, Inc.
Market Cap (USD): $8.27 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

29. ImmunoGen, Inc.

Company Profile: ImmunoGen, Inc.
Market Cap (USD): $8.25 B (Jan. 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

30. Cytokinetics, Incorporated

Company Profile: Cytokinetics, Incorporated
Market Cap (USD): $7.55 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

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