United States

Top 538 largest US Companies in the Biotechnology industry by Market Cap

This is the list of the largest public listed companies in the Biotechnology industry from the United States by market capitalization with links to their reference stock.

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Top Biotechnology Companies from the United States as of Jul. 01, 2025

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Rank Company Market Cap (USD) Country Sector Industry
1 Vertex Pharmaceuticals Incorporated $117.36 B United States US Healthcare US Biotechnology
2 Regeneron Pharmaceuticals, Inc. $59.14 B United States US Healthcare US Biotechnology
3 Seagen Inc. $43.15 B

(Dec. 1, 2023)

 United States US Healthcare US Biotechnology
4 Alnylam Pharmaceuticals, Inc. $43.00 B United States US Healthcare US Biotechnology
5 Viela Bio, Inc. $26.31 B United States US Healthcare US Biotechnology
6 Royalty Pharma plc $20.45 B United States US Healthcare US Biotechnology
7 Insmed Incorporated $18.66 B United States US Healthcare US Biotechnology
8 Summit Therapeutics Inc. $16.80 B United States US Healthcare US Biotechnology
9 Intra-Cellular Therapies, Inc. $13.50 B

(Jan. 1, 2025)

 United States US Healthcare US Biotechnology
10 United Therapeutics Corporation $13.32 B United States US Healthcare US Biotechnology
11 Incyte Corporation $13.20 B United States US Healthcare US Biotechnology
12 Neurocrine Biosciences, Inc. $12.78 B United States US Healthcare US Biotechnology
13 Exelixis, Inc. $12.08 B United States US Healthcare US Biotechnology
14 Karuna Therapeutics, Inc. $11.94 B

(Jan. 1, 2024)

 United States US Healthcare US Biotechnology
15 Moderna, Inc. $11.71 B United States US Healthcare US Biotechnology
16 BioMarin Pharmaceutical Inc. $10.96 B United States US Healthcare US Biotechnology
17 Acceleron Pharma Inc. $10.56 B

(Nov. 1, 2021)

 United States US Healthcare US Biotechnology
18 OncBioMune Pharmaceuticals, Inc. $8.67 B

(Feb. 1, 2022)

 United States US Healthcare US Biotechnology
19 Bio-Techne Corporation $8.34 B United States US Healthcare US Biotechnology
20 Blueprint Medicines Corporation $8.30 B United States US Healthcare US Biotechnology
21 ImmunoGen, Inc. $8.25 B

(Jan. 1, 2024)

 United States US Healthcare US Biotechnology
22 BridgeBio Pharma, Inc. $8.13 B United States US Healthcare US Biotechnology
23 Corcept Therapeutics Incorporated $7.66 B United States US Healthcare US Biotechnology
24 Cerevel Therapeutics Holdings, Inc. $7.46 B

(July 1, 2024)

 United States US Healthcare US Biotechnology
25 Revolution Medicines, Inc. $7.05 B United States US Healthcare US Biotechnology
26 Ionis Pharmaceuticals, Inc. $6.84 B United States US Healthcare US Biotechnology
27 Halozyme Therapeutics, Inc. $6.65 B United States US Healthcare US Biotechnology
28 Madrigal Pharmaceuticals, Inc. $6.64 B United States US Healthcare US Biotechnology
29 Legend Biotech Corporation $6.61 B United States US Healthcare US Biotechnology
30 Arena Pharmaceuticals, Inc. $6.17 B

(March 1, 2022)

 United States US Healthcare US Biotechnology

Top Biotechnology Companies from the United States as of Jul. 01, 2025

1. Vertex Pharmaceuticals Incorporated

Company Profile: Vertex Pharmaceuticals Incorporated
Market Cap (USD): $117.36 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

2. Regeneron Pharmaceuticals, Inc.

Company Profile: Regeneron Pharmaceuticals, Inc.
Market Cap (USD): $59.14 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

3. Seagen Inc.

Company Profile: Seagen Inc.
Market Cap (USD): $43.15 B (Dec. 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

4. Alnylam Pharmaceuticals, Inc.

Company Profile: Alnylam Pharmaceuticals, Inc.
Market Cap (USD): $43.00 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

5. Viela Bio, Inc.

Company Profile: Viela Bio, Inc.
Market Cap (USD): $26.31 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

6. Royalty Pharma plc

Company Profile: Royalty Pharma plc
Market Cap (USD): $20.45 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

7. Insmed Incorporated

Company Profile: Insmed Incorporated
Market Cap (USD): $18.66 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

8. Summit Therapeutics Inc.

Company Profile: Summit Therapeutics Inc.
Market Cap (USD): $16.80 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

9. Intra-Cellular Therapies, Inc.

Company Profile: Intra-Cellular Therapies, Inc.
Market Cap (USD): $13.50 B (Jan. 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

10. United Therapeutics Corporation

Company Profile: United Therapeutics Corporation
Market Cap (USD): $13.32 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

11. Incyte Corporation

Company Profile: Incyte Corporation
Market Cap (USD): $13.20 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

12. Neurocrine Biosciences, Inc.

Company Profile: Neurocrine Biosciences, Inc.
Market Cap (USD): $12.78 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

13. Exelixis, Inc.

Company Profile: Exelixis, Inc.
Market Cap (USD): $12.08 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

14. Karuna Therapeutics, Inc.

Company Profile: Karuna Therapeutics, Inc.
Market Cap (USD): $11.94 B (Jan. 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

15. Moderna, Inc.

Company Profile: Moderna, Inc.
Market Cap (USD): $11.71 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

16. BioMarin Pharmaceutical Inc.

Company Profile: BioMarin Pharmaceutical Inc.
Market Cap (USD): $10.96 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

17. Acceleron Pharma Inc.

Company Profile: Acceleron Pharma Inc.
Market Cap (USD): $10.56 B (Nov. 1, 2021)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

18. OncBioMune Pharmaceuticals, Inc.

Company Profile: OncBioMune Pharmaceuticals, Inc.
Market Cap (USD): $8.67 B (Feb. 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

19. Bio-Techne Corporation

Company Profile: Bio-Techne Corporation
Market Cap (USD): $8.34 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

20. Blueprint Medicines Corporation

Company Profile: Blueprint Medicines Corporation
Market Cap (USD): $8.30 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

21. ImmunoGen, Inc.

Company Profile: ImmunoGen, Inc.
Market Cap (USD): $8.25 B (Jan. 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

22. BridgeBio Pharma, Inc.

Company Profile: BridgeBio Pharma, Inc.
Market Cap (USD): $8.13 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

23. Corcept Therapeutics Incorporated

Company Profile: Corcept Therapeutics Incorporated
Market Cap (USD): $7.66 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

24. Cerevel Therapeutics Holdings, Inc.

Company Profile: Cerevel Therapeutics Holdings, Inc.
Market Cap (USD): $7.46 B (July 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

25. Revolution Medicines, Inc.

Company Profile: Revolution Medicines, Inc.
Market Cap (USD): $7.05 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

26. Ionis Pharmaceuticals, Inc.

Company Profile: Ionis Pharmaceuticals, Inc.
Market Cap (USD): $6.84 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

27. Halozyme Therapeutics, Inc.

Company Profile: Halozyme Therapeutics, Inc.
Market Cap (USD): $6.65 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

28. Madrigal Pharmaceuticals, Inc.

Company Profile: Madrigal Pharmaceuticals, Inc.
Market Cap (USD): $6.64 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

29. Legend Biotech Corporation

Company Profile: Legend Biotech Corporation
Market Cap (USD): $6.61 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

30. Arena Pharmaceuticals, Inc.

Company Profile: Arena Pharmaceuticals, Inc.
Market Cap (USD): $6.17 B (March 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

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