United States

Top 538 largest US Companies in the Biotechnology industry by Market Cap

This is the list of the largest public listed companies in the Biotechnology industry from the United States by market capitalization with links to their reference stock.

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Top Biotechnology Companies from the United States as of Jul. 01, 2025

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Rank Company Market Cap (USD) Country Sector Industry
31 TG Therapeutics, Inc. $5.83 B United States US Healthcare US Biotechnology
32 Axsome Therapeutics, Inc. $5.19 B United States US Healthcare US Biotechnology
33 Prometheus Biosciences, Inc. $4.95 B

(Jan. 1, 2023)

 United States US Healthcare US Biotechnology
34 Global Blood Therapeutics, Inc. $4.62 B

(Oct. 1, 2022)

 United States US Healthcare US Biotechnology
35 ADMA Biologics, Inc. $4.36 B United States US Healthcare US Biotechnology
36 Vaxcyte, Inc. $4.29 B United States US Healthcare US Biotechnology
37 Reata Pharmaceuticals, Inc. $4.19 B

(July 1, 2023)

 United States US Healthcare US Biotechnology
38 Rhythm Pharmaceuticals, Inc. $4.18 B United States US Healthcare US Biotechnology
39 Mirati Therapeutics, Inc. $4.15 B

(Jan. 1, 2024)

 United States US Healthcare US Biotechnology
40 Cytokinetics, Incorporated $4.14 B United States US Healthcare US Biotechnology
41 Krystal Biotech, Inc. $4.13 B United States US Healthcare US Biotechnology
42 Akero Therapeutics, Inc. $4.13 B United States US Healthcare US Biotechnology
43 PTC Therapeutics, Inc. $3.89 B United States US Healthcare US Biotechnology
44 Turning Point Therapeutics, Inc. $3.81 B

(Aug. 1, 2022)

 United States US Healthcare US Biotechnology
45 Ultragenyx Pharmaceutical Inc. $3.77 B United States US Healthcare US Biotechnology
46 ChemoCentryx, Inc. $3.74 B

(Oct. 1, 2022)

 United States US Healthcare US Biotechnology
47 SpringWorks Therapeutics, Inc. $3.54 B United States US Healthcare US Biotechnology
48 Avidity Biosciences, Inc. $3.52 B United States US Healthcare US Biotechnology
49 ACADIA Pharmaceuticals Inc. $3.51 B United States US Healthcare US Biotechnology
50 Scholar Rock Holding Corporation $3.42 B United States US Healthcare US Biotechnology
51 Viking Therapeutics, Inc. $3.17 B United States US Healthcare US Biotechnology
52 Protagonist Therapeutics, Inc. $3.16 B United States US Healthcare US Biotechnology
53 Kymera Therapeutics, Inc. $3.14 B United States US Healthcare US Biotechnology
54 VitaSpring Biomedical Co. Ltd $3.10 B United States US Healthcare US Biotechnology
55 Dicerna Pharmaceuticals, Inc. $2.93 B

(Dec. 1, 2021)

 United States US Healthcare US Biotechnology
56 Immunovant, Inc. $2.90 B United States US Healthcare US Biotechnology
57 NantKwest, Inc. $2.84 B United States US Healthcare US Biotechnology
58 Crinetics Pharmaceuticals, Inc. $2.76 B United States US Healthcare US Biotechnology
59 Chinook Therapeutics, Inc. $2.62 B

(July 1, 2023)

 United States US Healthcare US Biotechnology
60 Catalyst Pharmaceuticals, Inc. $2.62 B United States US Healthcare US Biotechnology

Top Biotechnology Companies from the United States as of Jul. 01, 2025

31. TG Therapeutics, Inc.

Company Profile: TG Therapeutics, Inc.
Market Cap (USD): $5.83 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

32. Axsome Therapeutics, Inc.

Company Profile: Axsome Therapeutics, Inc.
Market Cap (USD): $5.19 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

33. Prometheus Biosciences, Inc.

Company Profile: Prometheus Biosciences, Inc.
Market Cap (USD): $4.95 B (Jan. 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

34. Global Blood Therapeutics, Inc.

Company Profile: Global Blood Therapeutics, Inc.
Market Cap (USD): $4.62 B (Oct. 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

35. ADMA Biologics, Inc.

Company Profile: ADMA Biologics, Inc.
Market Cap (USD): $4.36 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

36. Vaxcyte, Inc.

Company Profile: Vaxcyte, Inc.
Market Cap (USD): $4.29 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

37. Reata Pharmaceuticals, Inc.

Company Profile: Reata Pharmaceuticals, Inc.
Market Cap (USD): $4.19 B (July 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

38. Rhythm Pharmaceuticals, Inc.

Company Profile: Rhythm Pharmaceuticals, Inc.
Market Cap (USD): $4.18 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

39. Mirati Therapeutics, Inc.

Company Profile: Mirati Therapeutics, Inc.
Market Cap (USD): $4.15 B (Jan. 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

40. Cytokinetics, Incorporated

Company Profile: Cytokinetics, Incorporated
Market Cap (USD): $4.14 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

41. Krystal Biotech, Inc.

Company Profile: Krystal Biotech, Inc.
Market Cap (USD): $4.13 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

42. Akero Therapeutics, Inc.

Company Profile: Akero Therapeutics, Inc.
Market Cap (USD): $4.13 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

43. PTC Therapeutics, Inc.

Company Profile: PTC Therapeutics, Inc.
Market Cap (USD): $3.89 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

44. Turning Point Therapeutics, Inc.

Company Profile: Turning Point Therapeutics, Inc.
Market Cap (USD): $3.81 B (Aug. 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

45. Ultragenyx Pharmaceutical Inc.

Company Profile: Ultragenyx Pharmaceutical Inc.
Market Cap (USD): $3.77 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

46. ChemoCentryx, Inc.

Company Profile: ChemoCentryx, Inc.
Market Cap (USD): $3.74 B (Oct. 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

47. SpringWorks Therapeutics, Inc.

Company Profile: SpringWorks Therapeutics, Inc.
Market Cap (USD): $3.54 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

48. Avidity Biosciences, Inc.

Company Profile: Avidity Biosciences, Inc.
Market Cap (USD): $3.52 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

49. ACADIA Pharmaceuticals Inc.

Company Profile: ACADIA Pharmaceuticals Inc.
Market Cap (USD): $3.51 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

50. Scholar Rock Holding Corporation

Company Profile: Scholar Rock Holding Corporation
Market Cap (USD): $3.42 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

51. Viking Therapeutics, Inc.

Company Profile: Viking Therapeutics, Inc.
Market Cap (USD): $3.17 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

52. Protagonist Therapeutics, Inc.

Company Profile: Protagonist Therapeutics, Inc.
Market Cap (USD): $3.16 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

53. Kymera Therapeutics, Inc.

Company Profile: Kymera Therapeutics, Inc.
Market Cap (USD): $3.14 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

54. VitaSpring Biomedical Co. Ltd

Company Profile: VitaSpring Biomedical Co. Ltd
Market Cap (USD): $3.10 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

55. Dicerna Pharmaceuticals, Inc.

Company Profile: Dicerna Pharmaceuticals, Inc.
Market Cap (USD): $2.93 B (Dec. 1, 2021)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

56. Immunovant, Inc.

Company Profile: Immunovant, Inc.
Market Cap (USD): $2.90 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

57. NantKwest, Inc.

Company Profile: NantKwest, Inc.
Market Cap (USD): $2.84 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

58. Crinetics Pharmaceuticals, Inc.

Company Profile: Crinetics Pharmaceuticals, Inc.
Market Cap (USD): $2.76 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

59. Chinook Therapeutics, Inc.

Company Profile: Chinook Therapeutics, Inc.
Market Cap (USD): $2.62 B (July 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

60. Catalyst Pharmaceuticals, Inc.

Company Profile: Catalyst Pharmaceuticals, Inc.
Market Cap (USD): $2.62 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

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