United States

Top 538 largest US Companies in the Biotechnology industry by Market Cap

This is the list of the largest public listed companies in the Biotechnology industry from the United States by market capitalization with links to their reference stock.

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Top Biotechnology Companies from the United States as of Jan. 01, 2026

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Rank Company Market Cap (USD) Country Sector Industry
31 Cerevel Therapeutics Holdings, Inc. $7.46 B

(July 1, 2024)

 United States US Healthcare US Biotechnology
32 Praxis Precision Medicines, Inc. $7.16 B United States US Healthcare US Biotechnology
33 Krystal Biotech, Inc. $7.16 B United States US Healthcare US Biotechnology
34 Rhythm Pharmaceuticals, Inc. $7.01 B United States US Healthcare US Biotechnology
35 Cidara Therapeutics, Inc. $6.95 B United States US Healthcare US Biotechnology
36 Arena Pharmaceuticals, Inc. $6.17 B

(March 1, 2022)

 United States US Healthcare US Biotechnology
37 PTC Therapeutics, Inc. $6.16 B United States US Healthcare US Biotechnology
38 Vaxcyte, Inc. $6.08 B United States US Healthcare US Biotechnology
39 Kymera Therapeutics, Inc. $5.82 B United States US Healthcare US Biotechnology
40 Protagonist Therapeutics, Inc. $5.45 B United States US Healthcare US Biotechnology
41 Cogent Biosciences, Inc. $5.33 B United States US Healthcare US Biotechnology
42 Immunovant, Inc. $5.22 B United States US Healthcare US Biotechnology
43 Prometheus Biosciences, Inc. $4.95 B

(Jan. 1, 2023)

 United States US Healthcare US Biotechnology
44 TG Therapeutics, Inc. $4.65 B United States US Healthcare US Biotechnology
45 Global Blood Therapeutics, Inc. $4.62 B

(Oct. 1, 2022)

 United States US Healthcare US Biotechnology
46 Akero Therapeutics, Inc. $4.50 B

(Dec. 1, 2025)

 United States US Healthcare US Biotechnology
47 ACADIA Pharmaceuticals Inc. $4.45 B United States US Healthcare US Biotechnology
48 Crinetics Pharmaceuticals, Inc. $4.43 B United States US Healthcare US Biotechnology
49 Amicus Therapeutics, Inc. $4.41 B United States US Healthcare US Biotechnology
50 Scholar Rock Holding Corporation $4.37 B United States US Healthcare US Biotechnology
51 Terns Pharmaceuticals, Inc. $4.36 B United States US Healthcare US Biotechnology
52 ADMA Biologics, Inc. $4.27 B United States US Healthcare US Biotechnology
53 Reata Pharmaceuticals, Inc. $4.19 B

(July 1, 2023)

 United States US Healthcare US Biotechnology
54 Mirati Therapeutics, Inc. $4.15 B

(Jan. 1, 2024)

 United States US Healthcare US Biotechnology
55 Mirum Pharmaceuticals, Inc. $4.03 B United States US Healthcare US Biotechnology
56 Corcept Therapeutics Incorporated $4.03 B United States US Healthcare US Biotechnology
57 Viking Therapeutics, Inc. $4.00 B United States US Healthcare US Biotechnology
58 Legend Biotech Corporation $3.97 B United States US Healthcare US Biotechnology
59 Turning Point Therapeutics, Inc. $3.81 B

(Aug. 1, 2022)

 United States US Healthcare US Biotechnology
60 Ligand Pharmaceuticals Incorporated $3.74 B United States US Healthcare US Biotechnology

Top Biotechnology Companies from the United States as of Jan. 01, 2026

31. Cerevel Therapeutics Holdings, Inc.

Company Profile: Cerevel Therapeutics Holdings, Inc.
Market Cap (USD): $7.46 B (July 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

32. Praxis Precision Medicines, Inc.

Company Profile: Praxis Precision Medicines, Inc.
Market Cap (USD): $7.16 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

33. Krystal Biotech, Inc.

Company Profile: Krystal Biotech, Inc.
Market Cap (USD): $7.16 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

34. Rhythm Pharmaceuticals, Inc.

Company Profile: Rhythm Pharmaceuticals, Inc.
Market Cap (USD): $7.01 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

35. Cidara Therapeutics, Inc.

Company Profile: Cidara Therapeutics, Inc.
Market Cap (USD): $6.95 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

36. Arena Pharmaceuticals, Inc.

Company Profile: Arena Pharmaceuticals, Inc.
Market Cap (USD): $6.17 B (March 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

37. PTC Therapeutics, Inc.

Company Profile: PTC Therapeutics, Inc.
Market Cap (USD): $6.16 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

38. Vaxcyte, Inc.

Company Profile: Vaxcyte, Inc.
Market Cap (USD): $6.08 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

39. Kymera Therapeutics, Inc.

Company Profile: Kymera Therapeutics, Inc.
Market Cap (USD): $5.82 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

40. Protagonist Therapeutics, Inc.

Company Profile: Protagonist Therapeutics, Inc.
Market Cap (USD): $5.45 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

41. Cogent Biosciences, Inc.

Company Profile: Cogent Biosciences, Inc.
Market Cap (USD): $5.33 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

42. Immunovant, Inc.

Company Profile: Immunovant, Inc.
Market Cap (USD): $5.22 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

43. Prometheus Biosciences, Inc.

Company Profile: Prometheus Biosciences, Inc.
Market Cap (USD): $4.95 B (Jan. 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

44. TG Therapeutics, Inc.

Company Profile: TG Therapeutics, Inc.
Market Cap (USD): $4.65 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

45. Global Blood Therapeutics, Inc.

Company Profile: Global Blood Therapeutics, Inc.
Market Cap (USD): $4.62 B (Oct. 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

46. Akero Therapeutics, Inc.

Company Profile: Akero Therapeutics, Inc.
Market Cap (USD): $4.50 B (Dec. 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

47. ACADIA Pharmaceuticals Inc.

Company Profile: ACADIA Pharmaceuticals Inc.
Market Cap (USD): $4.45 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

48. Crinetics Pharmaceuticals, Inc.

Company Profile: Crinetics Pharmaceuticals, Inc.
Market Cap (USD): $4.43 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

49. Amicus Therapeutics, Inc.

Company Profile: Amicus Therapeutics, Inc.
Market Cap (USD): $4.41 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

50. Scholar Rock Holding Corporation

Company Profile: Scholar Rock Holding Corporation
Market Cap (USD): $4.37 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

51. Terns Pharmaceuticals, Inc.

Company Profile: Terns Pharmaceuticals, Inc.
Market Cap (USD): $4.36 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

52. ADMA Biologics, Inc.

Company Profile: ADMA Biologics, Inc.
Market Cap (USD): $4.27 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

53. Reata Pharmaceuticals, Inc.

Company Profile: Reata Pharmaceuticals, Inc.
Market Cap (USD): $4.19 B (July 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

54. Mirati Therapeutics, Inc.

Company Profile: Mirati Therapeutics, Inc.
Market Cap (USD): $4.15 B (Jan. 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

55. Mirum Pharmaceuticals, Inc.

Company Profile: Mirum Pharmaceuticals, Inc.
Market Cap (USD): $4.03 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

56. Corcept Therapeutics Incorporated

Company Profile: Corcept Therapeutics Incorporated
Market Cap (USD): $4.03 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

57. Viking Therapeutics, Inc.

Company Profile: Viking Therapeutics, Inc.
Market Cap (USD): $4.00 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

58. Legend Biotech Corporation

Company Profile: Legend Biotech Corporation
Market Cap (USD): $3.97 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

59. Turning Point Therapeutics, Inc.

Company Profile: Turning Point Therapeutics, Inc.
Market Cap (USD): $3.81 B (Aug. 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

60. Ligand Pharmaceuticals Incorporated

Company Profile: Ligand Pharmaceuticals Incorporated
Market Cap (USD): $3.74 B
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

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