United States

Top 538 largest US Companies in the Biotechnology industry by Market Cap

This is the list of the largest public listed companies in the Biotechnology industry from the United States by market capitalization with links to their reference stock.

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Top Biotechnology Companies from the United States as of Jan. 01, 2026

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Rank Company Market Cap (USD) Country Sector Industry
151 Avid Bioservices, Inc. $796.3 M

(Jan. 1, 2025)

 United States US Healthcare US Biotechnology
152 ORIC Pharmaceuticals, Inc. $795.7 M United States US Healthcare US Biotechnology
153 Intercept Pharmaceuticals, Inc. $794.7 M

(Nov. 1, 2023)

 United States US Healthcare US Biotechnology
154 Aquestive Therapeutics, Inc. $786.9 M United States US Healthcare US Biotechnology
155 KalVista Pharmaceuticals, Inc. $781.4 M United States US Healthcare US Biotechnology
156 GlycoMimetics, Inc. $764.8 M United States US Healthcare US Biotechnology
157 Rigel Pharmaceuticals, Inc. $759.3 M United States US Healthcare US Biotechnology
158 CTI BioPharma Corp. $737.3 M

(Jan. 1, 2023)

 United States US Healthcare US Biotechnology
159 Fulcrum Therapeutics, Inc. $720.4 M United States US Healthcare US Biotechnology
160 CytomX Therapeutics, Inc. $720.1 M United States US Healthcare US Biotechnology
161 Annexon, Inc. $699.1 M United States US Healthcare US Biotechnology
162 Replimune Group, Inc. $698.1 M United States US Healthcare US Biotechnology
163 REGENXBIO Inc. $687.0 M United States US Healthcare US Biotechnology
164 Gossamer Bio, Inc. $666.6 M United States US Healthcare US Biotechnology
165 MeiraGTx Holdings plc $628.6 M United States US Healthcare US Biotechnology
166 Lyell Immunopharma, Inc. $615.6 M United States US Healthcare US Biotechnology
167 Cullinan Management, Inc. $597.9 M United States US Healthcare US Biotechnology
168 BioDelivery Sciences International, Inc. $577.1 M

(March 1, 2022)

 United States US Healthcare US Biotechnology
169 Sage Therapeutics, Inc. $576.1 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
170 Keros Therapeutics, Inc. $564.8 M United States US Healthcare US Biotechnology
171 Corvus Pharmaceuticals, Inc. $546.7 M United States US Healthcare US Biotechnology
172 Verastem, Inc. $544.6 M United States US Healthcare US Biotechnology
173 Assembly Biosciences, Inc. $533.7 M United States US Healthcare US Biotechnology
174 AVEO Pharmaceuticals, Inc. $521.4 M

(Jan. 1, 2023)

 United States US Healthcare US Biotechnology
175 Design Therapeutics, Inc. $518.4 M United States US Healthcare US Biotechnology
176 Akouos, Inc. $491.0 M

(Nov. 1, 2022)

 United States US Healthcare US Biotechnology
177 Vanda Pharmaceuticals Inc. $487.5 M United States US Healthcare US Biotechnology
178 ChromaDex Corporation $483.3 M United States US Healthcare US Biotechnology
179 SIGA Technologies, Inc. $449.0 M United States US Healthcare US Biotechnology
180 Eton Pharmaceuticals, Inc. $436.1 M United States US Healthcare US Biotechnology

Top Biotechnology Companies from the United States as of Jan. 01, 2026

151. Avid Bioservices, Inc.

Company Profile: Avid Bioservices, Inc.
Market Cap (USD): $796.3 M (Jan. 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

152. ORIC Pharmaceuticals, Inc.

Company Profile: ORIC Pharmaceuticals, Inc.
Market Cap (USD): $795.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

153. Intercept Pharmaceuticals, Inc.

Company Profile: Intercept Pharmaceuticals, Inc.
Market Cap (USD): $794.7 M (Nov. 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

154. Aquestive Therapeutics, Inc.

Company Profile: Aquestive Therapeutics, Inc.
Market Cap (USD): $786.9 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

155. KalVista Pharmaceuticals, Inc.

Company Profile: KalVista Pharmaceuticals, Inc.
Market Cap (USD): $781.4 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

156. GlycoMimetics, Inc.

Company Profile: GlycoMimetics, Inc.
Market Cap (USD): $764.8 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

157. Rigel Pharmaceuticals, Inc.

Company Profile: Rigel Pharmaceuticals, Inc.
Market Cap (USD): $759.3 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

158. CTI BioPharma Corp.

Company Profile: CTI BioPharma Corp.
Market Cap (USD): $737.3 M (Jan. 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

159. Fulcrum Therapeutics, Inc.

Company Profile: Fulcrum Therapeutics, Inc.
Market Cap (USD): $720.4 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

160. CytomX Therapeutics, Inc.

Company Profile: CytomX Therapeutics, Inc.
Market Cap (USD): $720.1 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

161. Annexon, Inc.

Company Profile: Annexon, Inc.
Market Cap (USD): $699.1 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

162. Replimune Group, Inc.

Company Profile: Replimune Group, Inc.
Market Cap (USD): $698.1 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

163. REGENXBIO Inc.

Company Profile: REGENXBIO Inc.
Market Cap (USD): $687.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

164. Gossamer Bio, Inc.

Company Profile: Gossamer Bio, Inc.
Market Cap (USD): $666.6 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

165. MeiraGTx Holdings plc

Company Profile: MeiraGTx Holdings plc
Market Cap (USD): $628.6 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

166. Lyell Immunopharma, Inc.

Company Profile: Lyell Immunopharma, Inc.
Market Cap (USD): $615.6 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

167. Cullinan Management, Inc.

Company Profile: Cullinan Management, Inc.
Market Cap (USD): $597.9 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

168. BioDelivery Sciences International, Inc.

Company Profile: BioDelivery Sciences International, Inc.
Market Cap (USD): $577.1 M (March 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

169. Sage Therapeutics, Inc.

Company Profile: Sage Therapeutics, Inc.
Market Cap (USD): $576.1 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

170. Keros Therapeutics, Inc.

Company Profile: Keros Therapeutics, Inc.
Market Cap (USD): $564.8 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

171. Corvus Pharmaceuticals, Inc.

Company Profile: Corvus Pharmaceuticals, Inc.
Market Cap (USD): $546.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

172. Verastem, Inc.

Company Profile: Verastem, Inc.
Market Cap (USD): $544.6 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

173. Assembly Biosciences, Inc.

Company Profile: Assembly Biosciences, Inc.
Market Cap (USD): $533.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

174. AVEO Pharmaceuticals, Inc.

Company Profile: AVEO Pharmaceuticals, Inc.
Market Cap (USD): $521.4 M (Jan. 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

175. Design Therapeutics, Inc.

Company Profile: Design Therapeutics, Inc.
Market Cap (USD): $518.4 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

176. Akouos, Inc.

Company Profile: Akouos, Inc.
Market Cap (USD): $491.0 M (Nov. 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

177. Vanda Pharmaceuticals Inc.

Company Profile: Vanda Pharmaceuticals Inc.
Market Cap (USD): $487.5 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

178. ChromaDex Corporation

Company Profile: ChromaDex Corporation
Market Cap (USD): $483.3 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

179. SIGA Technologies, Inc.

Company Profile: SIGA Technologies, Inc.
Market Cap (USD): $449.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

180. Eton Pharmaceuticals, Inc.

Company Profile: Eton Pharmaceuticals, Inc.
Market Cap (USD): $436.1 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

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