United States

Top 538 largest US Companies in the Biotechnology industry by Market Cap

This is the list of the largest public listed companies in the Biotechnology industry from the United States by market capitalization with links to their reference stock.

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Top Biotechnology Companies from the United States as of Jan. 01, 2026

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Rank Company Market Cap (USD) Country Sector Industry
211 Abeona Therapeutics Inc. $287.8 M United States US Healthcare US Biotechnology
212 Cerecor Inc. $285.0 M

(June 1, 2022)

 United States US Healthcare US Biotechnology
213 Aldeyra Therapeutics, Inc. $281.0 M United States US Healthcare US Biotechnology
214 Frontage Holdings Corp $276.2 M United States US Healthcare US Biotechnology
215 Atea Pharmaceuticals, Inc. $271.9 M United States US Healthcare US Biotechnology
216 Greenwich LifeSciences, Inc. $269.7 M United States US Healthcare US Biotechnology
217 Fennec Pharmaceuticals Inc. $262.3 M United States US Healthcare US Biotechnology
218 Galectin Therapeutics, Inc. $261.1 M United States US Healthcare US Biotechnology
219 Inozyme Pharma, Inc. $258.2 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
220 Vor Biopharma, Inc. $255.0 M United States US Healthcare US Biotechnology
221 Chiasma, Inc. $253.0 M

(July 1, 2021)

 United States US Healthcare US Biotechnology
222 Epizyme, Inc. $247.5 M

(Aug. 1, 2022)

 United States US Healthcare US Biotechnology
223 Nautilus Biotechnology, Inc. $241.2 M United States US Healthcare US Biotechnology
224 Armata Pharmaceuticals Inc. $238.8 M United States US Healthcare US Biotechnology
225 Inhibikase Therapeutics, Inc. $236.5 M United States US Healthcare US Biotechnology
226 Shattuck Labs, Inc. $234.8 M United States US Healthcare US Biotechnology
227 Checkmate Pharmaceuticals, Inc. $231.4 M

(May 1, 2022)

 United States US Healthcare US Biotechnology
228 Heron Therapeutics, Inc. $231.0 M United States US Healthcare US Biotechnology
229 Voyager Therapeutics, Inc. $224.1 M United States US Healthcare US Biotechnology
230 Cabaletta Bio, Inc. $212.7 M United States US Healthcare US Biotechnology
231 scPharmaceuticals Inc. $209.6 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
232 VitaSpring Biomedical Co. Ltd $207.0 M United States US Healthcare US Biotechnology
233 Zevra Therapeutics, Inc. $205.3 M

(Jan. 1, 2023)

 United States US Healthcare US Biotechnology
234 LogicBio Therapeutics, Inc. $201.7 M United States US Healthcare US Biotechnology
235 Editas Medicine, Inc. $200.1 M United States US Healthcare US Biotechnology
236 Y-mAbs Therapeutics, Inc. $194.8 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
237 Spectrum Pharmaceuticals, Inc. $192.9 M

(July 1, 2023)

 United States US Healthcare US Biotechnology
238 Merrimack Pharmaceuticals, Inc. $189.8 M

(Jan. 1, 2024)

 United States US Healthcare US Biotechnology
239 ZIOPHARM Oncology, Inc. $187.1 M

(June 1, 2022)

 United States US Healthcare US Biotechnology
240 C4 Therapeutics, Inc. $187.0 M United States US Healthcare US Biotechnology

Top Biotechnology Companies from the United States as of Jan. 01, 2026

211. Abeona Therapeutics Inc.

Company Profile: Abeona Therapeutics Inc.
Market Cap (USD): $287.8 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

212. Cerecor Inc.

Company Profile: Cerecor Inc.
Market Cap (USD): $285.0 M (June 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

213. Aldeyra Therapeutics, Inc.

Company Profile: Aldeyra Therapeutics, Inc.
Market Cap (USD): $281.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

214. Frontage Holdings Corp

Company Profile: Frontage Holdings Corp
Market Cap (USD): $276.2 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

215. Atea Pharmaceuticals, Inc.

Company Profile: Atea Pharmaceuticals, Inc.
Market Cap (USD): $271.9 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

216. Greenwich LifeSciences, Inc.

Company Profile: Greenwich LifeSciences, Inc.
Market Cap (USD): $269.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

217. Fennec Pharmaceuticals Inc.

Company Profile: Fennec Pharmaceuticals Inc.
Market Cap (USD): $262.3 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

218. Galectin Therapeutics, Inc.

Company Profile: Galectin Therapeutics, Inc.
Market Cap (USD): $261.1 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

219. Inozyme Pharma, Inc.

Company Profile: Inozyme Pharma, Inc.
Market Cap (USD): $258.2 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

220. Vor Biopharma, Inc.

Company Profile: Vor Biopharma, Inc.
Market Cap (USD): $255.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

221. Chiasma, Inc.

Company Profile: Chiasma, Inc.
Market Cap (USD): $253.0 M (July 1, 2021)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

222. Epizyme, Inc.

Company Profile: Epizyme, Inc.
Market Cap (USD): $247.5 M (Aug. 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

223. Nautilus Biotechnology, Inc.

Company Profile: Nautilus Biotechnology, Inc.
Market Cap (USD): $241.2 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

224. Armata Pharmaceuticals Inc.

Company Profile: Armata Pharmaceuticals Inc.
Market Cap (USD): $238.8 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

225. Inhibikase Therapeutics, Inc.

Company Profile: Inhibikase Therapeutics, Inc.
Market Cap (USD): $236.5 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

226. Shattuck Labs, Inc.

Company Profile: Shattuck Labs, Inc.
Market Cap (USD): $234.8 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

227. Checkmate Pharmaceuticals, Inc.

Company Profile: Checkmate Pharmaceuticals, Inc.
Market Cap (USD): $231.4 M (May 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

228. Heron Therapeutics, Inc.

Company Profile: Heron Therapeutics, Inc.
Market Cap (USD): $231.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

229. Voyager Therapeutics, Inc.

Company Profile: Voyager Therapeutics, Inc.
Market Cap (USD): $224.1 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

230. Cabaletta Bio, Inc.

Company Profile: Cabaletta Bio, Inc.
Market Cap (USD): $212.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

231. scPharmaceuticals Inc.

Company Profile: scPharmaceuticals Inc.
Market Cap (USD): $209.6 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

232. VitaSpring Biomedical Co. Ltd

Company Profile: VitaSpring Biomedical Co. Ltd
Market Cap (USD): $207.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

233. Zevra Therapeutics, Inc.

Company Profile: Zevra Therapeutics, Inc.
Market Cap (USD): $205.3 M (Jan. 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

234. LogicBio Therapeutics, Inc.

Company Profile: LogicBio Therapeutics, Inc.
Market Cap (USD): $201.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

235. Editas Medicine, Inc.

Company Profile: Editas Medicine, Inc.
Market Cap (USD): $200.1 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

236. Y-mAbs Therapeutics, Inc.

Company Profile: Y-mAbs Therapeutics, Inc.
Market Cap (USD): $194.8 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

237. Spectrum Pharmaceuticals, Inc.

Company Profile: Spectrum Pharmaceuticals, Inc.
Market Cap (USD): $192.9 M (July 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

238. Merrimack Pharmaceuticals, Inc.

Company Profile: Merrimack Pharmaceuticals, Inc.
Market Cap (USD): $189.8 M (Jan. 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

239. ZIOPHARM Oncology, Inc.

Company Profile: ZIOPHARM Oncology, Inc.
Market Cap (USD): $187.1 M (June 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

240. C4 Therapeutics, Inc.

Company Profile: C4 Therapeutics, Inc.
Market Cap (USD): $187.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

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