United States

Top 538 largest US Companies in the Biotechnology industry by Market Cap

This is the list of the largest public listed companies in the Biotechnology industry from the United States by market capitalization with links to their reference stock.

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Top Biotechnology Companies from the United States as of Jan. 01, 2026

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Rank Company Market Cap (USD) Country Sector Industry
271 Inovio Pharmaceuticals, Inc. $116.1 M United States US Healthcare US Biotechnology
272 Oramed Pharmaceuticals Inc. $116.0 M United States US Healthcare US Biotechnology
273 Fate Therapeutics, Inc. $113.8 M United States US Healthcare US Biotechnology
274 Kinnate Biopharma Inc. $113.5 M

(Jan. 1, 2024)

 United States US Healthcare US Biotechnology
275 NGM Biopharmaceuticals, Inc. $110.8 M

(Jan. 1, 2024)

 United States US Healthcare US Biotechnology
276 Agenus Inc. $109.8 M United States US Healthcare US Biotechnology
277 Catabasis Pharmaceuticals, Inc. $109.5 M

(June 1, 2022)

 United States US Healthcare US Biotechnology
278 Cyteir Therapeutics, Inc. $109.1 M

(Jan. 1, 2024)

 United States US Healthcare US Biotechnology
279 Allakos Inc. $108.1 M

(Jan. 1, 2025)

 United States US Healthcare US Biotechnology
280 Opiant Pharmaceuticals, Inc. $107.5 M

(Jan. 1, 2023)

 United States US Healthcare US Biotechnology
281 Entasis Therapeutics Holdings Inc. $104.8 M

(June 1, 2024)

 United States US Healthcare US Biotechnology
282 Seer, Inc. $102.4 M United States US Healthcare US Biotechnology
283 MacroGenics, Inc. $101.8 M United States US Healthcare US Biotechnology
284 Jounce Therapeutics, Inc. $101.6 M

(May 1, 2023)

 United States US Healthcare US Biotechnology
285 Cassava Sciences, Inc. $101.0 M United States US Healthcare US Biotechnology
286 Zentalis Pharmaceuticals, Inc. $99.0 M United States US Healthcare US Biotechnology
287 Spruce Biosciences, Inc. $97.1 M United States US Healthcare US Biotechnology
288 Annovis Bio, Inc. $96.7 M United States US Healthcare US Biotechnology
289 Adverum Biotechnologies, Inc. $96.3 M

(Dec. 1, 2025)

 United States US Healthcare US Biotechnology
290 Biomea Fusion, Inc. $94.7 M United States US Healthcare US Biotechnology
291 Champions Oncology, Inc. $92.5 M United States US Healthcare US Biotechnology
292 Osmotica Pharmaceuticals plc $92.5 M

(June 1, 2022)

 United States US Healthcare US Biotechnology
293 BeyondSpring Inc. $89.9 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
294 Veru Inc. $88.9 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
295 Vaxart, Inc. $86.2 M United States US Healthcare US Biotechnology
296 IGM Biosciences, Inc. $81.9 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
297 Atossa Therapeutics, Inc. $81.5 M United States US Healthcare US Biotechnology
298 Eyenovia, Inc. $80.8 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
299 Decibel Therapeutics, Inc. $80.3 M

(July 1, 2023)

 United States US Healthcare US Biotechnology
300 Pliant Therapeutics, Inc. $77.3 M

(July 1, 2025)

 United States US Healthcare US Biotechnology

Top Biotechnology Companies from the United States as of Jan. 01, 2026

271. Inovio Pharmaceuticals, Inc.

Company Profile: Inovio Pharmaceuticals, Inc.
Market Cap (USD): $116.1 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

272. Oramed Pharmaceuticals Inc.

Company Profile: Oramed Pharmaceuticals Inc.
Market Cap (USD): $116.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

273. Fate Therapeutics, Inc.

Company Profile: Fate Therapeutics, Inc.
Market Cap (USD): $113.8 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

274. Kinnate Biopharma Inc.

Company Profile: Kinnate Biopharma Inc.
Market Cap (USD): $113.5 M (Jan. 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

275. NGM Biopharmaceuticals, Inc.

Company Profile: NGM Biopharmaceuticals, Inc.
Market Cap (USD): $110.8 M (Jan. 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

276. Agenus Inc.

Company Profile: Agenus Inc.
Market Cap (USD): $109.8 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

277. Catabasis Pharmaceuticals, Inc.

Company Profile: Catabasis Pharmaceuticals, Inc.
Market Cap (USD): $109.5 M (June 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

278. Cyteir Therapeutics, Inc.

Company Profile: Cyteir Therapeutics, Inc.
Market Cap (USD): $109.1 M (Jan. 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

279. Allakos Inc.

Company Profile: Allakos Inc.
Market Cap (USD): $108.1 M (Jan. 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

280. Opiant Pharmaceuticals, Inc.

Company Profile: Opiant Pharmaceuticals, Inc.
Market Cap (USD): $107.5 M (Jan. 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

281. Entasis Therapeutics Holdings Inc.

Company Profile: Entasis Therapeutics Holdings Inc.
Market Cap (USD): $104.8 M (June 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

282. Seer, Inc.

Company Profile: Seer, Inc.
Market Cap (USD): $102.4 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

283. MacroGenics, Inc.

Company Profile: MacroGenics, Inc.
Market Cap (USD): $101.8 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

284. Jounce Therapeutics, Inc.

Company Profile: Jounce Therapeutics, Inc.
Market Cap (USD): $101.6 M (May 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

285. Cassava Sciences, Inc.

Company Profile: Cassava Sciences, Inc.
Market Cap (USD): $101.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

286. Zentalis Pharmaceuticals, Inc.

Company Profile: Zentalis Pharmaceuticals, Inc.
Market Cap (USD): $99.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

287. Spruce Biosciences, Inc.

Company Profile: Spruce Biosciences, Inc.
Market Cap (USD): $97.1 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

288. Annovis Bio, Inc.

Company Profile: Annovis Bio, Inc.
Market Cap (USD): $96.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

289. Adverum Biotechnologies, Inc.

Company Profile: Adverum Biotechnologies, Inc.
Market Cap (USD): $96.3 M (Dec. 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

290. Biomea Fusion, Inc.

Company Profile: Biomea Fusion, Inc.
Market Cap (USD): $94.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

291. Champions Oncology, Inc.

Company Profile: Champions Oncology, Inc.
Market Cap (USD): $92.5 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

292. Osmotica Pharmaceuticals plc

Company Profile: Osmotica Pharmaceuticals plc
Market Cap (USD): $92.5 M (June 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

293. BeyondSpring Inc.

Company Profile: BeyondSpring Inc.
Market Cap (USD): $89.9 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

294. Veru Inc.

Company Profile: Veru Inc.
Market Cap (USD): $88.9 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

295. Vaxart, Inc.

Company Profile: Vaxart, Inc.
Market Cap (USD): $86.2 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

296. IGM Biosciences, Inc.

Company Profile: IGM Biosciences, Inc.
Market Cap (USD): $81.9 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

297. Atossa Therapeutics, Inc.

Company Profile: Atossa Therapeutics, Inc.
Market Cap (USD): $81.5 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

298. Eyenovia, Inc.

Company Profile: Eyenovia, Inc.
Market Cap (USD): $80.8 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

299. Decibel Therapeutics, Inc.

Company Profile: Decibel Therapeutics, Inc.
Market Cap (USD): $80.3 M (July 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

300. Pliant Therapeutics, Inc.

Company Profile: Pliant Therapeutics, Inc.
Market Cap (USD): $77.3 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

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