United States

Top 538 largest US Companies in the Biotechnology industry by Market Cap

This is the list of the largest public listed companies in the Biotechnology industry from the United States by market capitalization with links to their reference stock.

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Top Biotechnology Companies from the United States as of Jan. 01, 2026

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Rank Company Market Cap (USD) Country Sector Industry
301 bluebird bio, Inc. $76.5 M

(Jan. 1, 2025)

 United States US Healthcare US Biotechnology
302 Instil Bio, Inc. $76.4 M United States US Healthcare US Biotechnology
303 Outlook Therapeutics, Inc. $76.3 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
304 Biostage, Inc. $75.9 M

(Jan. 1, 2023)

 United States US Healthcare US Biotechnology
305 XBiotech Inc. $72.6 M United States US Healthcare US Biotechnology
306 Immunic, Inc. $69.7 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
307 Anebulo Pharmaceuticals, Inc. $69.0 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
308 BioStem Technologies, Inc. $66.7 M United States US Healthcare US Biotechnology
309 Biotech Products Services and Research, Inc. $66.1 M

(Nov. 1, 2021)

 United States US Healthcare US Biotechnology
310 Aerpio Pharmaceuticals, Inc. $66.0 M

(July 1, 2024)

 United States US Healthcare US Biotechnology
311 Verrica Pharmaceuticals Inc. $65.4 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
312 Sutro Biopharma, Inc. $64.5 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
313 Ikena Oncology, Inc. $64.2 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
314 Leap Therapeutics, Inc. $64.0 M United States US Healthcare US Biotechnology
315 Clearside Biomedical, Inc. $63.1 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
316 Gritstone bio, Inc. $63.0 M

(July 1, 2024)

 United States US Healthcare US Biotechnology
317 ALX Oncology Holdings Inc. $62.4 M United States US Healthcare US Biotechnology
318 PMV Pharmaceuticals, Inc. $61.8 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
319 MediciNova, Inc. $61.3 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
320 Surface Oncology, Inc. $59.2 M

(July 1, 2023)

 United States US Healthcare US Biotechnology
321 VistaGen Therapeutics, Inc. $58.3 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
322 Atara Biotherapeutics, Inc. $57.5 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
323 Artemis Therapeutics, Inc. $55.8 M

(May 1, 2023)

 United States US Healthcare US Biotechnology
324 aTyr Pharma, Inc. $54.0 M United States US Healthcare US Biotechnology
325 Kronos Bio, Inc. $53.7 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
326 Tyme Technologies, Inc. $53.5 M

(Sept. 1, 2022)

 United States US Healthcare US Biotechnology
327 Sigilon Therapeutics, Inc. $53.3 M

(July 1, 2023)

 United States US Healthcare US Biotechnology
328 ABVC BioPharma, Inc. $53.2 M United States US Healthcare US Biotechnology
329 Cue Biopharma, Inc. $52.4 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
330 Ocuphire Pharma, Inc. $50.8 M United States US Healthcare US Biotechnology

Top Biotechnology Companies from the United States as of Jan. 01, 2026

301. bluebird bio, Inc.

Company Profile: bluebird bio, Inc.
Market Cap (USD): $76.5 M (Jan. 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

302. Instil Bio, Inc.

Company Profile: Instil Bio, Inc.
Market Cap (USD): $76.4 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

303. Outlook Therapeutics, Inc.

Company Profile: Outlook Therapeutics, Inc.
Market Cap (USD): $76.3 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

304. Biostage, Inc.

Company Profile: Biostage, Inc.
Market Cap (USD): $75.9 M (Jan. 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

305. XBiotech Inc.

Company Profile: XBiotech Inc.
Market Cap (USD): $72.6 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

306. Immunic, Inc.

Company Profile: Immunic, Inc.
Market Cap (USD): $69.7 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

307. Anebulo Pharmaceuticals, Inc.

Company Profile: Anebulo Pharmaceuticals, Inc.
Market Cap (USD): $69.0 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

308. BioStem Technologies, Inc.

Company Profile: BioStem Technologies, Inc.
Market Cap (USD): $66.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

309. Biotech Products Services and Research, Inc.

Company Profile: Biotech Products Services and Research, Inc.
Market Cap (USD): $66.1 M (Nov. 1, 2021)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

310. Aerpio Pharmaceuticals, Inc.

Company Profile: Aerpio Pharmaceuticals, Inc.
Market Cap (USD): $66.0 M (July 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

311. Verrica Pharmaceuticals Inc.

Company Profile: Verrica Pharmaceuticals Inc.
Market Cap (USD): $65.4 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

312. Sutro Biopharma, Inc.

Company Profile: Sutro Biopharma, Inc.
Market Cap (USD): $64.5 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

313. Ikena Oncology, Inc.

Company Profile: Ikena Oncology, Inc.
Market Cap (USD): $64.2 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

314. Leap Therapeutics, Inc.

Company Profile: Leap Therapeutics, Inc.
Market Cap (USD): $64.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

315. Clearside Biomedical, Inc.

Company Profile: Clearside Biomedical, Inc.
Market Cap (USD): $63.1 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

316. Gritstone bio, Inc.

Company Profile: Gritstone bio, Inc.
Market Cap (USD): $63.0 M (July 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

317. ALX Oncology Holdings Inc.

Company Profile: ALX Oncology Holdings Inc.
Market Cap (USD): $62.4 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

318. PMV Pharmaceuticals, Inc.

Company Profile: PMV Pharmaceuticals, Inc.
Market Cap (USD): $61.8 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

319. MediciNova, Inc.

Company Profile: MediciNova, Inc.
Market Cap (USD): $61.3 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

320. Surface Oncology, Inc.

Company Profile: Surface Oncology, Inc.
Market Cap (USD): $59.2 M (July 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

321. VistaGen Therapeutics, Inc.

Company Profile: VistaGen Therapeutics, Inc.
Market Cap (USD): $58.3 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

322. Atara Biotherapeutics, Inc.

Company Profile: Atara Biotherapeutics, Inc.
Market Cap (USD): $57.5 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

323. Artemis Therapeutics, Inc.

Company Profile: Artemis Therapeutics, Inc.
Market Cap (USD): $55.8 M (May 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

324. aTyr Pharma, Inc.

Company Profile: aTyr Pharma, Inc.
Market Cap (USD): $54.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

325. Kronos Bio, Inc.

Company Profile: Kronos Bio, Inc.
Market Cap (USD): $53.7 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

326. Tyme Technologies, Inc.

Company Profile: Tyme Technologies, Inc.
Market Cap (USD): $53.5 M (Sept. 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

327. Sigilon Therapeutics, Inc.

Company Profile: Sigilon Therapeutics, Inc.
Market Cap (USD): $53.3 M (July 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

328. ABVC BioPharma, Inc.

Company Profile: ABVC BioPharma, Inc.
Market Cap (USD): $53.2 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

329. Cue Biopharma, Inc.

Company Profile: Cue Biopharma, Inc.
Market Cap (USD): $52.4 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

330. Ocuphire Pharma, Inc.

Company Profile: Ocuphire Pharma, Inc.
Market Cap (USD): $50.8 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

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