United States

Top 538 largest US Companies in the Biotechnology industry by Market Cap

This is the list of the largest public listed companies in the Biotechnology industry from the United States by market capitalization with links to their reference stock.

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Top Biotechnology Companies from the United States as of Jan. 01, 2026

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Rank Company Market Cap (USD) Country Sector Industry
181 Ocugen, Inc. $431.0 M United States US Healthcare US Biotechnology
182 4D Molecular Therapeutics, Inc. $418.2 M United States US Healthcare US Biotechnology
183 Enanta Pharmaceuticals, Inc. $416.2 M United States US Healthcare US Biotechnology
184 Lexicon Pharmaceuticals, Inc. $414.3 M United States US Healthcare US Biotechnology
185 IMARA Inc. $413.7 M United States US Healthcare US Biotechnology
186 DiaMedica Therapeutics Inc. $413.0 M United States US Healthcare US Biotechnology
187 Akebia Therapeutics, Inc. $411.3 M United States US Healthcare US Biotechnology
188 PureTech Health plc $410.9 M United States US Healthcare US Biotechnology
189 Concert Pharmaceuticals, Inc. $401.9 M

(June 1, 2024)

 United States US Healthcare US Biotechnology
190 Northwest Biotherapeutics, Inc. $392.7 M United States US Healthcare US Biotechnology
191 iTeos Therapeutics, Inc. $389.6 M

(July 1, 2025)

 United States US Healthcare US Biotechnology
192 Revance Therapeutics, Inc. $381.0 M

(Jan. 1, 2025)

 United States US Healthcare US Biotechnology
193 Cerus Corporation $378.4 M United States US Healthcare US Biotechnology
194 Lineage Cell Therapeutics, Inc. $377.7 M United States US Healthcare US Biotechnology
195 Rocket Pharmaceuticals, Inc. $374.4 M United States US Healthcare US Biotechnology
196 Palisade Bio, Inc. $373.0 M United States US Healthcare US Biotechnology
197 Altimmune, Inc. $366.2 M United States US Healthcare US Biotechnology
198 AzurRx BioPharma, Inc. $366.2 M United States US Healthcare US Biotechnology
199 Chimerix, Inc. $356.3 M

(Jan. 1, 2025)

 United States US Healthcare US Biotechnology
200 XOMA Corporation $346.6 M United States US Healthcare US Biotechnology
201 Silverback Therapeutics, Inc. $341.8 M

(July 1, 2024)

 United States US Healthcare US Biotechnology
202 CytoDyn, Inc. $341.8 M United States US Healthcare US Biotechnology
203 X4 Pharmaceuticals, Inc. $340.1 M United States US Healthcare US Biotechnology
204 Anavex Life Sciences Corp. $328.8 M United States US Healthcare US Biotechnology
205 Aclaris Therapeutics, Inc. $312.0 M United States US Healthcare US Biotechnology
206 Allogene Therapeutics, Inc. $303.4 M United States US Healthcare US Biotechnology
207 Oyster Point Pharma, Inc. $299.9 M

(Dec. 1, 2022)

 United States US Healthcare US Biotechnology
208 Larimar Therapeutics, Inc. $297.0 M United States US Healthcare US Biotechnology
209 Foghorn Therapeutics Inc. $293.5 M United States US Healthcare US Biotechnology
210 Puma Biotechnology, Inc. $290.8 M United States US Healthcare US Biotechnology

Top Biotechnology Companies from the United States as of Jan. 01, 2026

181. Ocugen, Inc.

Company Profile: Ocugen, Inc.
Market Cap (USD): $431.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

182. 4D Molecular Therapeutics, Inc.

Company Profile: 4D Molecular Therapeutics, Inc.
Market Cap (USD): $418.2 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

183. Enanta Pharmaceuticals, Inc.

Company Profile: Enanta Pharmaceuticals, Inc.
Market Cap (USD): $416.2 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

184. Lexicon Pharmaceuticals, Inc.

Company Profile: Lexicon Pharmaceuticals, Inc.
Market Cap (USD): $414.3 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

185. IMARA Inc.

Company Profile: IMARA Inc.
Market Cap (USD): $413.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

186. DiaMedica Therapeutics Inc.

Company Profile: DiaMedica Therapeutics Inc.
Market Cap (USD): $413.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

187. Akebia Therapeutics, Inc.

Company Profile: Akebia Therapeutics, Inc.
Market Cap (USD): $411.3 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

188. PureTech Health plc

Company Profile: PureTech Health plc
Market Cap (USD): $410.9 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

189. Concert Pharmaceuticals, Inc.

Company Profile: Concert Pharmaceuticals, Inc.
Market Cap (USD): $401.9 M (June 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

190. Northwest Biotherapeutics, Inc.

Company Profile: Northwest Biotherapeutics, Inc.
Market Cap (USD): $392.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

191. iTeos Therapeutics, Inc.

Company Profile: iTeos Therapeutics, Inc.
Market Cap (USD): $389.6 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

192. Revance Therapeutics, Inc.

Company Profile: Revance Therapeutics, Inc.
Market Cap (USD): $381.0 M (Jan. 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

193. Cerus Corporation

Company Profile: Cerus Corporation
Market Cap (USD): $378.4 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

194. Lineage Cell Therapeutics, Inc.

Company Profile: Lineage Cell Therapeutics, Inc.
Market Cap (USD): $377.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

195. Rocket Pharmaceuticals, Inc.

Company Profile: Rocket Pharmaceuticals, Inc.
Market Cap (USD): $374.4 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

196. Palisade Bio, Inc.

Company Profile: Palisade Bio, Inc.
Market Cap (USD): $373.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

197. Altimmune, Inc.

Company Profile: Altimmune, Inc.
Market Cap (USD): $366.2 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

198. AzurRx BioPharma, Inc.

Company Profile: AzurRx BioPharma, Inc.
Market Cap (USD): $366.2 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

199. Chimerix, Inc.

Company Profile: Chimerix, Inc.
Market Cap (USD): $356.3 M (Jan. 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

200. XOMA Corporation

Company Profile: XOMA Corporation
Market Cap (USD): $346.6 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

201. Silverback Therapeutics, Inc.

Company Profile: Silverback Therapeutics, Inc.
Market Cap (USD): $341.8 M (July 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

202. CytoDyn, Inc.

Company Profile: CytoDyn, Inc.
Market Cap (USD): $341.8 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

203. X4 Pharmaceuticals, Inc.

Company Profile: X4 Pharmaceuticals, Inc.
Market Cap (USD): $340.1 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

204. Anavex Life Sciences Corp.

Company Profile: Anavex Life Sciences Corp.
Market Cap (USD): $328.8 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

205. Aclaris Therapeutics, Inc.

Company Profile: Aclaris Therapeutics, Inc.
Market Cap (USD): $312.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

206. Allogene Therapeutics, Inc.

Company Profile: Allogene Therapeutics, Inc.
Market Cap (USD): $303.4 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

207. Oyster Point Pharma, Inc.

Company Profile: Oyster Point Pharma, Inc.
Market Cap (USD): $299.9 M (Dec. 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

208. Larimar Therapeutics, Inc.

Company Profile: Larimar Therapeutics, Inc.
Market Cap (USD): $297.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

209. Foghorn Therapeutics Inc.

Company Profile: Foghorn Therapeutics Inc.
Market Cap (USD): $293.5 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

210. Puma Biotechnology, Inc.

Company Profile: Puma Biotechnology, Inc.
Market Cap (USD): $290.8 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

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