United States

Top 538 largest US Companies in the Biotechnology industry by Market Cap

This is the list of the largest public listed companies in the Biotechnology industry from the United States by market capitalization with links to their reference stock.

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Top Biotechnology Companies from the United States as of Jul. 01, 2025

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Rank Company Market Cap (USD) Country Sector Industry
181 Lexicon Pharmaceuticals, Inc. $327.2 M United States US Healthcare US Biotechnology
182 XOMA Corporation $322.6 M United States US Healthcare US Biotechnology
183 Atea Pharmaceuticals, Inc. $320.1 M United States US Healthcare US Biotechnology
184 Annexon, Inc. $317.1 M United States US Healthcare US Biotechnology
185 Olema Pharmaceuticals, Inc. $312.7 M United States US Healthcare US Biotechnology
186 Rocket Pharmaceuticals, Inc. $312.4 M United States US Healthcare US Biotechnology
187 Nektar Therapeutics $307.2 M United States US Healthcare US Biotechnology
188 Corvus Pharmaceuticals, Inc. $304.6 M United States US Healthcare US Biotechnology
189 Abeona Therapeutics Inc. $301.3 M United States US Healthcare US Biotechnology
190 Oyster Point Pharma, Inc. $299.9 M

(Dec. 1, 2022)

 United States US Healthcare US Biotechnology
191 Cerus Corporation $294.4 M United States US Healthcare US Biotechnology
192 Vanda Pharmaceuticals Inc. $292.9 M United States US Healthcare US Biotechnology
193 Foghorn Therapeutics Inc. $286.0 M United States US Healthcare US Biotechnology
194 Cerecor Inc. $285.0 M

(June 1, 2022)

 United States US Healthcare US Biotechnology
195 Gossamer Bio, Inc. $281.9 M United States US Healthcare US Biotechnology
196 Ocugen, Inc. $279.5 M United States US Healthcare US Biotechnology
197 Frontage Holdings Corp $278.4 M United States US Healthcare US Biotechnology
198 Verastem, Inc. $263.8 M United States US Healthcare US Biotechnology
199 Allogene Therapeutics, Inc. $260.3 M United States US Healthcare US Biotechnology
200 Inozyme Pharma, Inc. $258.2 M United States US Healthcare US Biotechnology
201 Aldeyra Therapeutics, Inc. $257.6 M United States US Healthcare US Biotechnology
202 Chiasma, Inc. $253.0 M

(July 1, 2021)

 United States US Healthcare US Biotechnology
203 Epizyme, Inc. $247.5 M

(Aug. 1, 2022)

 United States US Healthcare US Biotechnology
204 Cardiff Oncology, Inc. $243.5 M United States US Healthcare US Biotechnology
205 Fennec Pharmaceuticals Inc. $243.0 M United States US Healthcare US Biotechnology
206 Vor Biopharma, Inc. $238.7 M United States US Healthcare US Biotechnology
207 Inhibrx, Inc. $236.4 M United States US Healthcare US Biotechnology
208 Esperion Therapeutics, Inc. $231.9 M United States US Healthcare US Biotechnology
209 Checkmate Pharmaceuticals, Inc. $231.4 M

(May 1, 2022)

 United States US Healthcare US Biotechnology
210 Lineage Cell Therapeutics, Inc. $230.6 M United States US Healthcare US Biotechnology

Top Biotechnology Companies from the United States as of Jul. 01, 2025

181. Lexicon Pharmaceuticals, Inc.

Company Profile: Lexicon Pharmaceuticals, Inc.
Market Cap (USD): $327.2 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

182. XOMA Corporation

Company Profile: XOMA Corporation
Market Cap (USD): $322.6 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

183. Atea Pharmaceuticals, Inc.

Company Profile: Atea Pharmaceuticals, Inc.
Market Cap (USD): $320.1 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

184. Annexon, Inc.

Company Profile: Annexon, Inc.
Market Cap (USD): $317.1 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

185. Olema Pharmaceuticals, Inc.

Company Profile: Olema Pharmaceuticals, Inc.
Market Cap (USD): $312.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

186. Rocket Pharmaceuticals, Inc.

Company Profile: Rocket Pharmaceuticals, Inc.
Market Cap (USD): $312.4 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

187. Nektar Therapeutics

Company Profile: Nektar Therapeutics
Market Cap (USD): $307.2 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

188. Corvus Pharmaceuticals, Inc.

Company Profile: Corvus Pharmaceuticals, Inc.
Market Cap (USD): $304.6 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

189. Abeona Therapeutics Inc.

Company Profile: Abeona Therapeutics Inc.
Market Cap (USD): $301.3 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

190. Oyster Point Pharma, Inc.

Company Profile: Oyster Point Pharma, Inc.
Market Cap (USD): $299.9 M (Dec. 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

191. Cerus Corporation

Company Profile: Cerus Corporation
Market Cap (USD): $294.4 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

192. Vanda Pharmaceuticals Inc.

Company Profile: Vanda Pharmaceuticals Inc.
Market Cap (USD): $292.9 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

193. Foghorn Therapeutics Inc.

Company Profile: Foghorn Therapeutics Inc.
Market Cap (USD): $286.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

194. Cerecor Inc.

Company Profile: Cerecor Inc.
Market Cap (USD): $285.0 M (June 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

195. Gossamer Bio, Inc.

Company Profile: Gossamer Bio, Inc.
Market Cap (USD): $281.9 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

196. Ocugen, Inc.

Company Profile: Ocugen, Inc.
Market Cap (USD): $279.5 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

197. Frontage Holdings Corp

Company Profile: Frontage Holdings Corp
Market Cap (USD): $278.4 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

198. Verastem, Inc.

Company Profile: Verastem, Inc.
Market Cap (USD): $263.8 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

199. Allogene Therapeutics, Inc.

Company Profile: Allogene Therapeutics, Inc.
Market Cap (USD): $260.3 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

200. Inozyme Pharma, Inc.

Company Profile: Inozyme Pharma, Inc.
Market Cap (USD): $258.2 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

201. Aldeyra Therapeutics, Inc.

Company Profile: Aldeyra Therapeutics, Inc.
Market Cap (USD): $257.6 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

202. Chiasma, Inc.

Company Profile: Chiasma, Inc.
Market Cap (USD): $253.0 M (July 1, 2021)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

203. Epizyme, Inc.

Company Profile: Epizyme, Inc.
Market Cap (USD): $247.5 M (Aug. 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

204. Cardiff Oncology, Inc.

Company Profile: Cardiff Oncology, Inc.
Market Cap (USD): $243.5 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

205. Fennec Pharmaceuticals Inc.

Company Profile: Fennec Pharmaceuticals Inc.
Market Cap (USD): $243.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

206. Vor Biopharma, Inc.

Company Profile: Vor Biopharma, Inc.
Market Cap (USD): $238.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

207. Inhibrx, Inc.

Company Profile: Inhibrx, Inc.
Market Cap (USD): $236.4 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

208. Esperion Therapeutics, Inc.

Company Profile: Esperion Therapeutics, Inc.
Market Cap (USD): $231.9 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

209. Checkmate Pharmaceuticals, Inc.

Company Profile: Checkmate Pharmaceuticals, Inc.
Market Cap (USD): $231.4 M (May 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

210. Lineage Cell Therapeutics, Inc.

Company Profile: Lineage Cell Therapeutics, Inc.
Market Cap (USD): $230.6 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

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