United States

Top 538 largest US Companies in the Biotechnology industry by Market Cap

This is the list of the largest public listed companies in the Biotechnology industry from the United States by market capitalization with links to their reference stock.

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Top Biotechnology Companies from the United States as of Jul. 01, 2025

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Rank Company Market Cap (USD) Country Sector Industry
361 Longeveron, Inc. $19.7 M United States US Healthcare US Biotechnology
362 Vallon Pharmaceuticals, Inc. $19.4 M United States US Healthcare US Biotechnology
363 Curis, Inc. $18.9 M United States US Healthcare US Biotechnology
364 Metacrine, Inc. $18.8 M

(Jan. 1, 2023)

 United States US Healthcare US Biotechnology
365 Acorda Therapeutics, Inc. $18.0 M

(Jan. 1, 2024)

 United States US Healthcare US Biotechnology
366 BioVie Inc. $17.8 M United States US Healthcare US Biotechnology
367 Acer Therapeutics Inc. $16.1 M

(Nov. 1, 2023)

 United States US Healthcare US Biotechnology
368 Hoth Therapeutics, Inc. $16.0 M United States US Healthcare US Biotechnology
369 Lyra Therapeutics, Inc. $15.7 M United States US Healthcare US Biotechnology
370 Cocrystal Pharma, Inc. $15.5 M United States US Healthcare US Biotechnology
371 HOOKIPA Pharma Inc. $15.0 M United States US Healthcare US Biotechnology
372 Frequency Therapeutics, Inc. $14.3 M

(July 1, 2023)

 United States US Healthcare US Biotechnology
373 Landos Biopharma, Inc. $13.7 M

(Jan. 1, 2024)

 United States US Healthcare US Biotechnology
374 X4 Pharmaceuticals, Inc. $13.6 M United States US Healthcare US Biotechnology
375 Athira Pharma, Inc. $13.3 M United States US Healthcare US Biotechnology
376 CEL-SCI Corporation $12.8 M United States US Healthcare US Biotechnology
377 Leap Therapeutics, Inc. $12.1 M United States US Healthcare US Biotechnology
378 Cyclerion Therapeutics, Inc. $12.0 M United States US Healthcare US Biotechnology
379 BioXcel Therapeutics, Inc. $11.7 M United States US Healthcare US Biotechnology
380 Sensei Biotherapeutics, Inc. $11.4 M United States US Healthcare US Biotechnology
381 Applied Molecular Transport Inc. $11.0 M

(Dec. 1, 2023)

 United States US Healthcare US Biotechnology
382 BioCardia, Inc. $11.0 M United States US Healthcare US Biotechnology
383 Synaptogenix, Inc. $10.9 M United States US Healthcare US Biotechnology
384 GlycoMimetics, Inc. $10.1 M United States US Healthcare US Biotechnology
385 Aprea Therapeutics, Inc. $9.6 M United States US Healthcare US Biotechnology
386 Aravive, Inc. $8.9 M

(Jan. 1, 2024)

 United States US Healthcare US Biotechnology
387 Moleculin Biotech, Inc. $8.2 M United States US Healthcare US Biotechnology
388 Cara Therapeutics, Inc. $8.1 M

(April 1, 2025)

 United States US Healthcare US Biotechnology
389 Orgenesis Inc. $6.9 M United States US Healthcare US Biotechnology
390 Aptinyx Inc. $6.5 M

(Dec. 1, 2023)

 United States US Healthcare US Biotechnology

Top Biotechnology Companies from the United States as of Jul. 01, 2025

361. Longeveron, Inc.

Company Profile: Longeveron, Inc.
Market Cap (USD): $19.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

362. Vallon Pharmaceuticals, Inc.

Company Profile: Vallon Pharmaceuticals, Inc.
Market Cap (USD): $19.4 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

363. Curis, Inc.

Company Profile: Curis, Inc.
Market Cap (USD): $18.9 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

364. Metacrine, Inc.

Company Profile: Metacrine, Inc.
Market Cap (USD): $18.8 M (Jan. 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

365. Acorda Therapeutics, Inc.

Company Profile: Acorda Therapeutics, Inc.
Market Cap (USD): $18.0 M (Jan. 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

366. BioVie Inc.

Company Profile: BioVie Inc.
Market Cap (USD): $17.8 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

367. Acer Therapeutics Inc.

Company Profile: Acer Therapeutics Inc.
Market Cap (USD): $16.1 M (Nov. 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

368. Hoth Therapeutics, Inc.

Company Profile: Hoth Therapeutics, Inc.
Market Cap (USD): $16.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

369. Lyra Therapeutics, Inc.

Company Profile: Lyra Therapeutics, Inc.
Market Cap (USD): $15.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

370. Cocrystal Pharma, Inc.

Company Profile: Cocrystal Pharma, Inc.
Market Cap (USD): $15.5 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

371. HOOKIPA Pharma Inc.

Company Profile: HOOKIPA Pharma Inc.
Market Cap (USD): $15.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

372. Frequency Therapeutics, Inc.

Company Profile: Frequency Therapeutics, Inc.
Market Cap (USD): $14.3 M (July 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

373. Landos Biopharma, Inc.

Company Profile: Landos Biopharma, Inc.
Market Cap (USD): $13.7 M (Jan. 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

374. X4 Pharmaceuticals, Inc.

Company Profile: X4 Pharmaceuticals, Inc.
Market Cap (USD): $13.6 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

375. Athira Pharma, Inc.

Company Profile: Athira Pharma, Inc.
Market Cap (USD): $13.3 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

376. CEL-SCI Corporation

Company Profile: CEL-SCI Corporation
Market Cap (USD): $12.8 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

377. Leap Therapeutics, Inc.

Company Profile: Leap Therapeutics, Inc.
Market Cap (USD): $12.1 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

378. Cyclerion Therapeutics, Inc.

Company Profile: Cyclerion Therapeutics, Inc.
Market Cap (USD): $12.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

379. BioXcel Therapeutics, Inc.

Company Profile: BioXcel Therapeutics, Inc.
Market Cap (USD): $11.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

380. Sensei Biotherapeutics, Inc.

Company Profile: Sensei Biotherapeutics, Inc.
Market Cap (USD): $11.4 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

381. Applied Molecular Transport Inc.

Company Profile: Applied Molecular Transport Inc.
Market Cap (USD): $11.0 M (Dec. 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

382. BioCardia, Inc.

Company Profile: BioCardia, Inc.
Market Cap (USD): $11.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

383. Synaptogenix, Inc.

Company Profile: Synaptogenix, Inc.
Market Cap (USD): $10.9 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

384. GlycoMimetics, Inc.

Company Profile: GlycoMimetics, Inc.
Market Cap (USD): $10.1 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

385. Aprea Therapeutics, Inc.

Company Profile: Aprea Therapeutics, Inc.
Market Cap (USD): $9.6 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

386. Aravive, Inc.

Company Profile: Aravive, Inc.
Market Cap (USD): $8.9 M (Jan. 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

387. Moleculin Biotech, Inc.

Company Profile: Moleculin Biotech, Inc.
Market Cap (USD): $8.2 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

388. Cara Therapeutics, Inc.

Company Profile: Cara Therapeutics, Inc.
Market Cap (USD): $8.1 M (April 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

389. Orgenesis Inc.

Company Profile: Orgenesis Inc.
Market Cap (USD): $6.9 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

390. Aptinyx Inc.

Company Profile: Aptinyx Inc.
Market Cap (USD): $6.5 M (Dec. 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

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