United States

Top 538 largest US Companies in the Biotechnology industry by Market Cap

This is the list of the largest public listed companies in the Biotechnology industry from the United States by market capitalization with links to their reference stock.

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Top Biotechnology Companies from the United States as of Jan. 01, 2026

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Rank Company Market Cap (USD) Country Sector Industry
361 Onconova Therapeutics, Inc. $23.7 M United States US Healthcare US Biotechnology
362 Finch Therapeutics Group, Inc. $21.7 M United States US Healthcare US Biotechnology
363 Yumanity Therapeutics, Inc. $20.5 M

(Dec. 1, 2022)

 United States US Healthcare US Biotechnology
364 NeuroBo Pharmaceuticals, Inc. $20.3 M

(Jan. 1, 2025)

 United States US Healthcare US Biotechnology
365 VYNE Therapeutics Inc. $19.3 M United States US Healthcare US Biotechnology
366 Metacrine, Inc. $18.8 M

(Jan. 1, 2023)

 United States US Healthcare US Biotechnology
367 Acorda Therapeutics, Inc. $18.0 M

(Jan. 1, 2024)

 United States US Healthcare US Biotechnology
368 Citius Pharmaceuticals, Inc. $17.6 M United States US Healthcare US Biotechnology
369 CASI Pharmaceuticals, Inc. $16.9 M United States US Healthcare US Biotechnology
370 Hoth Therapeutics, Inc. $16.6 M United States US Healthcare US Biotechnology
371 Acer Therapeutics Inc. $16.1 M

(Nov. 1, 2023)

 United States US Healthcare US Biotechnology
372 Applied Therapeutics, Inc. $14.8 M United States US Healthcare US Biotechnology
373 Soligenix, Inc. $14.3 M United States US Healthcare US Biotechnology
374 Frequency Therapeutics, Inc. $14.3 M

(July 1, 2023)

 United States US Healthcare US Biotechnology
375 Cocrystal Pharma, Inc. $13.7 M United States US Healthcare US Biotechnology
376 Landos Biopharma, Inc. $13.7 M

(Jan. 1, 2024)

 United States US Healthcare US Biotechnology
377 BioCardia, Inc. $13.5 M United States US Healthcare US Biotechnology
378 Curis, Inc. $12.7 M United States US Healthcare US Biotechnology
379 Longeveron, Inc. $12.7 M United States US Healthcare US Biotechnology
380 Sensei Biotherapeutics, Inc. $12.2 M United States US Healthcare US Biotechnology
381 HOOKIPA Pharma Inc. $11.0 M United States US Healthcare US Biotechnology
382 Applied Molecular Transport Inc. $11.0 M

(Dec. 1, 2023)

 United States US Healthcare US Biotechnology
383 BioVie Inc. $10.0 M United States US Healthcare US Biotechnology
384 Aravive, Inc. $8.9 M

(Jan. 1, 2024)

 United States US Healthcare US Biotechnology
385 Cara Therapeutics, Inc. $8.1 M

(April 1, 2025)

 United States US Healthcare US Biotechnology
386 Moleculin Biotech, Inc. $7.5 M United States US Healthcare US Biotechnology
387 Aptinyx Inc. $6.5 M

(Dec. 1, 2023)

 United States US Healthcare US Biotechnology
388 Adial Pharmaceuticals, Inc. $6.4 M United States US Healthcare US Biotechnology
389 Aprea Therapeutics, Inc. $6.0 M United States US Healthcare US Biotechnology
390 Titan Pharmaceuticals, Inc. $5.9 M

(July 1, 2025)

 United States US Healthcare US Biotechnology

Top Biotechnology Companies from the United States as of Jan. 01, 2026

361. Onconova Therapeutics, Inc.

Company Profile: Onconova Therapeutics, Inc.
Market Cap (USD): $23.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

362. Finch Therapeutics Group, Inc.

Company Profile: Finch Therapeutics Group, Inc.
Market Cap (USD): $21.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

363. Yumanity Therapeutics, Inc.

Company Profile: Yumanity Therapeutics, Inc.
Market Cap (USD): $20.5 M (Dec. 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

364. NeuroBo Pharmaceuticals, Inc.

Company Profile: NeuroBo Pharmaceuticals, Inc.
Market Cap (USD): $20.3 M (Jan. 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

365. VYNE Therapeutics Inc.

Company Profile: VYNE Therapeutics Inc.
Market Cap (USD): $19.3 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

366. Metacrine, Inc.

Company Profile: Metacrine, Inc.
Market Cap (USD): $18.8 M (Jan. 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

367. Acorda Therapeutics, Inc.

Company Profile: Acorda Therapeutics, Inc.
Market Cap (USD): $18.0 M (Jan. 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

368. Citius Pharmaceuticals, Inc.

Company Profile: Citius Pharmaceuticals, Inc.
Market Cap (USD): $17.6 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

369. CASI Pharmaceuticals, Inc.

Company Profile: CASI Pharmaceuticals, Inc.
Market Cap (USD): $16.9 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

370. Hoth Therapeutics, Inc.

Company Profile: Hoth Therapeutics, Inc.
Market Cap (USD): $16.6 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

371. Acer Therapeutics Inc.

Company Profile: Acer Therapeutics Inc.
Market Cap (USD): $16.1 M (Nov. 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

372. Applied Therapeutics, Inc.

Company Profile: Applied Therapeutics, Inc.
Market Cap (USD): $14.8 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

373. Soligenix, Inc.

Company Profile: Soligenix, Inc.
Market Cap (USD): $14.3 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

374. Frequency Therapeutics, Inc.

Company Profile: Frequency Therapeutics, Inc.
Market Cap (USD): $14.3 M (July 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

375. Cocrystal Pharma, Inc.

Company Profile: Cocrystal Pharma, Inc.
Market Cap (USD): $13.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

376. Landos Biopharma, Inc.

Company Profile: Landos Biopharma, Inc.
Market Cap (USD): $13.7 M (Jan. 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

377. BioCardia, Inc.

Company Profile: BioCardia, Inc.
Market Cap (USD): $13.5 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

378. Curis, Inc.

Company Profile: Curis, Inc.
Market Cap (USD): $12.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

379. Longeveron, Inc.

Company Profile: Longeveron, Inc.
Market Cap (USD): $12.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

380. Sensei Biotherapeutics, Inc.

Company Profile: Sensei Biotherapeutics, Inc.
Market Cap (USD): $12.2 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

381. HOOKIPA Pharma Inc.

Company Profile: HOOKIPA Pharma Inc.
Market Cap (USD): $11.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

382. Applied Molecular Transport Inc.

Company Profile: Applied Molecular Transport Inc.
Market Cap (USD): $11.0 M (Dec. 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

383. BioVie Inc.

Company Profile: BioVie Inc.
Market Cap (USD): $10.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

384. Aravive, Inc.

Company Profile: Aravive, Inc.
Market Cap (USD): $8.9 M (Jan. 1, 2024)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

385. Cara Therapeutics, Inc.

Company Profile: Cara Therapeutics, Inc.
Market Cap (USD): $8.1 M (April 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

386. Moleculin Biotech, Inc.

Company Profile: Moleculin Biotech, Inc.
Market Cap (USD): $7.5 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

387. Aptinyx Inc.

Company Profile: Aptinyx Inc.
Market Cap (USD): $6.5 M (Dec. 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

388. Adial Pharmaceuticals, Inc.

Company Profile: Adial Pharmaceuticals, Inc.
Market Cap (USD): $6.4 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

389. Aprea Therapeutics, Inc.

Company Profile: Aprea Therapeutics, Inc.
Market Cap (USD): $6.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

390. Titan Pharmaceuticals, Inc.

Company Profile: Titan Pharmaceuticals, Inc.
Market Cap (USD): $5.9 M (July 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

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