United States

Top 538 largest US Companies in the Biotechnology industry by Market Cap

This is the list of the largest public listed companies in the Biotechnology industry from the United States by market capitalization with links to their reference stock.

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Top Biotechnology Companies from the United States as of Jul. 01, 2025

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Rank Company Market Cap (USD) Country Sector Industry
331 Applied Therapeutics, Inc. $45.3 M United States US Healthcare US Biotechnology
332 Actinium Pharmaceuticals, Inc. $44.9 M United States US Healthcare US Biotechnology
333 Prelude Therapeutics Incorporated $44.8 M United States US Healthcare US Biotechnology
334 Shattuck Labs, Inc. $39.9 M United States US Healthcare US Biotechnology
335 Karyopharm Therapeutics Inc. $37.9 M United States US Healthcare US Biotechnology
336 Mersana Therapeutics, Inc. $36.1 M United States US Healthcare US Biotechnology
337 Lantern Pharma Inc. $35.1 M United States US Healthcare US Biotechnology
338 Kezar Life Sciences, Inc. $33.5 M United States US Healthcare US Biotechnology
339 Ocuphire Pharma, Inc. $31.7 M United States US Healthcare US Biotechnology
340 AzurRx BioPharma, Inc. $31.7 M United States US Healthcare US Biotechnology
341 Angion Biomedica Corp $30.1 M

(June 1, 2023)

 United States US Healthcare US Biotechnology
342 Marinus Pharmaceuticals, Inc. $29.9 M

(Jan. 1, 2025)

 United States US Healthcare US Biotechnology
343 Passage Bio, Inc. $28.7 M United States US Healthcare US Biotechnology
344 Dyadic International, Inc. $28.3 M United States US Healthcare US Biotechnology
345 Cyclo Therapeutics, Inc. $26.9 M

(Jan. 1, 2025)

 United States US Healthcare US Biotechnology
346 Rain Therapeutics, Inc. $25.3 M United States US Healthcare US Biotechnology
347 Citius Pharmaceuticals, Inc. $24.7 M United States US Healthcare US Biotechnology
348 ALX Oncology Holdings Inc. $24.6 M United States US Healthcare US Biotechnology
349 Reviva Pharmaceuticals Holdings, Inc. $24.5 M United States US Healthcare US Biotechnology
350 Ovid Therapeutics Inc. $24.1 M United States US Healthcare US Biotechnology
351 VYNE Therapeutics Inc. $23.7 M United States US Healthcare US Biotechnology
352 Generation Bio Co. $23.0 M United States US Healthcare US Biotechnology
353 FibroGen, Inc. $22.7 M United States US Healthcare US Biotechnology
354 BioAtla, Inc. $22.0 M United States US Healthcare US Biotechnology
355 Aytu BioScience, Inc. $21.4 M United States US Healthcare US Biotechnology
356 Finch Therapeutics Group, Inc. $21.2 M United States US Healthcare US Biotechnology
357 Onconova Therapeutics, Inc. $20.9 M United States US Healthcare US Biotechnology
358 Yumanity Therapeutics, Inc. $20.5 M

(Dec. 1, 2022)

 United States US Healthcare US Biotechnology
359 NeuroBo Pharmaceuticals, Inc. $20.3 M

(Jan. 1, 2025)

 United States US Healthcare US Biotechnology
360 CASI Pharmaceuticals, Inc. $20.1 M United States US Healthcare US Biotechnology

Top Biotechnology Companies from the United States as of Jul. 01, 2025

331. Applied Therapeutics, Inc.

Company Profile: Applied Therapeutics, Inc.
Market Cap (USD): $45.3 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

332. Actinium Pharmaceuticals, Inc.

Company Profile: Actinium Pharmaceuticals, Inc.
Market Cap (USD): $44.9 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

333. Prelude Therapeutics Incorporated

Company Profile: Prelude Therapeutics Incorporated
Market Cap (USD): $44.8 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

334. Shattuck Labs, Inc.

Company Profile: Shattuck Labs, Inc.
Market Cap (USD): $39.9 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

335. Karyopharm Therapeutics Inc.

Company Profile: Karyopharm Therapeutics Inc.
Market Cap (USD): $37.9 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

336. Mersana Therapeutics, Inc.

Company Profile: Mersana Therapeutics, Inc.
Market Cap (USD): $36.1 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

337. Lantern Pharma Inc.

Company Profile: Lantern Pharma Inc.
Market Cap (USD): $35.1 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

338. Kezar Life Sciences, Inc.

Company Profile: Kezar Life Sciences, Inc.
Market Cap (USD): $33.5 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

339. Ocuphire Pharma, Inc.

Company Profile: Ocuphire Pharma, Inc.
Market Cap (USD): $31.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

340. AzurRx BioPharma, Inc.

Company Profile: AzurRx BioPharma, Inc.
Market Cap (USD): $31.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

341. Angion Biomedica Corp

Company Profile: Angion Biomedica Corp
Market Cap (USD): $30.1 M (June 1, 2023)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

342. Marinus Pharmaceuticals, Inc.

Company Profile: Marinus Pharmaceuticals, Inc.
Market Cap (USD): $29.9 M (Jan. 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

343. Passage Bio, Inc.

Company Profile: Passage Bio, Inc.
Market Cap (USD): $28.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

344. Dyadic International, Inc.

Company Profile: Dyadic International, Inc.
Market Cap (USD): $28.3 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

345. Cyclo Therapeutics, Inc.

Company Profile: Cyclo Therapeutics, Inc.
Market Cap (USD): $26.9 M (Jan. 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

346. Rain Therapeutics, Inc.

Company Profile: Rain Therapeutics, Inc.
Market Cap (USD): $25.3 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

347. Citius Pharmaceuticals, Inc.

Company Profile: Citius Pharmaceuticals, Inc.
Market Cap (USD): $24.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

348. ALX Oncology Holdings Inc.

Company Profile: ALX Oncology Holdings Inc.
Market Cap (USD): $24.6 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

349. Reviva Pharmaceuticals Holdings, Inc.

Company Profile: Reviva Pharmaceuticals Holdings, Inc.
Market Cap (USD): $24.5 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

350. Ovid Therapeutics Inc.

Company Profile: Ovid Therapeutics Inc.
Market Cap (USD): $24.1 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

351. VYNE Therapeutics Inc.

Company Profile: VYNE Therapeutics Inc.
Market Cap (USD): $23.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

352. Generation Bio Co.

Company Profile: Generation Bio Co.
Market Cap (USD): $23.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

353. FibroGen, Inc.

Company Profile: FibroGen, Inc.
Market Cap (USD): $22.7 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

354. BioAtla, Inc.

Company Profile: BioAtla, Inc.
Market Cap (USD): $22.0 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

355. Aytu BioScience, Inc.

Company Profile: Aytu BioScience, Inc.
Market Cap (USD): $21.4 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

356. Finch Therapeutics Group, Inc.

Company Profile: Finch Therapeutics Group, Inc.
Market Cap (USD): $21.2 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

357. Onconova Therapeutics, Inc.

Company Profile: Onconova Therapeutics, Inc.
Market Cap (USD): $20.9 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

358. Yumanity Therapeutics, Inc.

Company Profile: Yumanity Therapeutics, Inc.
Market Cap (USD): $20.5 M (Dec. 1, 2022)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

359. NeuroBo Pharmaceuticals, Inc.

Company Profile: NeuroBo Pharmaceuticals, Inc.
Market Cap (USD): $20.3 M (Jan. 1, 2025)
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

360. CASI Pharmaceuticals, Inc.

Company Profile: CASI Pharmaceuticals, Inc.
Market Cap (USD): $20.1 M
Country: United States
Sector: US Healthcare
Industry: US Biotechnology

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